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A part of the credit of all rare and unique treatments one gets from Sreedhareeyam Ayurveda Gaveshana Kendram can be attributed to the long tradition and experience of the "vaidyans" or physicians belonging to the 'Nellikkattu Mana' over the generations. Nellikattu Mana and their extraordinary knowledge in the science of Ayurveda have a long history, of which the origin could be traced back to the 19th century. Men of this family were well known for anti-venom and eye treatments even in those days.

The family originally belonged to a remote village in North Kerala named Sukapuram. They were said to be popular in that part of the world when they decided to migrate to Koothattukulam in Ernakulam district in central Kerala. They attribute their talents and special acumen in curing rare diseases to the blessings of their favorite Deity 'Thirumandhamkunnu Bhagavathi'.

All the treatments offered at Sreedhareeyam Ayurveda Gaveshana Kendram starts with a special prayer to Thirumandhamkunnu Bhagavathi.